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5-HTP is a naturally occurring amino acid that the body converts into serotonin, a neurotransmitter that regulates mood, appetite, and sleep. Supplementing with 5-HTP can help support healthy sleep patterns and may help increase serotonin.


Triple Strength 5-HTP contains 300mg of highly absorbent 5-hydroxytryptophan (5-HTP), which is three times the strength of most other leading brands’ products, and up to 6 times the strength of many others.

Each Triple Strength 5-HTP tablet is further enhanced with 5mg of Black Pepper Extract, boosting absorption by up to 2000%, and Vitamins C and B6, both essential for converting 5-HTP to serotonin.

We uphold the highest standards of quality, purity, and transparency with every batch of Triple Strength 5-HTP by subjecting it to rigorous testing throughout each of the carefully selected manufacturing processes, as well as third-party testing of the finished product.

Additionally, each bottle contains 90 tablets, up to 3 months supply, providing exceptional value for money.

Key Features:

  • 3x more 5-HTP than most other options (300mg vs an average of 100mg)
  • Rigorous testing and transparency ensures you know exactly what you are putting in your body.
  • With Black Pepper Extract to increase the absorption by up to 2000%.
  • Added Vitamins B6 and C help convert 5-HTP to serotonin.
  • Outstanding value: 90 tablets per bottle, up to 3 months of use.
Sleep, Calming, Stress Relief

Triple Strength 5-HTP - High Absorption

Triple Dose 300mg x 90 tablets

250+ purchased this past month

300mg of 5-HTP in every tablet, enhanced with vitamins and piperine for maximum benefits, and at a fraction of the high street prices.

Featured Review

“Tried so many 5-HTP and these are the only ones I buy now. Fantastic quality. Cannot recommend highly enough”

- Cole A.

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5-HTP is a naturally occurring amino acid that the body converts into serotonin, a neurotransmitter that regulates mood, appetite, and sleep. Supplementing with 5-HTP can help support healthy sleep patterns and may help increase serotonin.


Triple Strength 5-HTP contains 300mg of highly absorbent 5-hydroxytryptophan (5-HTP), which is three times the strength of most other leading brands’ products, and up to 6 times the strength of many others.

Each Triple Strength 5-HTP tablet is further enhanced with 5mg of Black Pepper Extract, boosting absorption by up to 2000%, and Vitamins C and B6, both essential for converting 5-HTP to serotonin.

We uphold the highest standards of quality, purity, and transparency with every batch of Triple Strength 5-HTP by subjecting it to rigorous testing throughout each of the carefully selected manufacturing processes, as well as third-party testing of the finished product.

Additionally, each bottle contains 90 tablets, up to 3 months supply, providing exceptional value for money.

Key Features:

  • 3x more 5-HTP than most other options (300mg vs an average of 100mg)
  • Rigorous testing and transparency ensures you know exactly what you are putting in your body.
  • With Black Pepper Extract to increase the absorption by up to 2000%.
  • Added Vitamins B6 and C help convert 5-HTP to serotonin.
  • Outstanding value: 90 tablets per bottle, up to 3 months of use.
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Triple Strength 5-HTP

3X Stronger

Our annual audit of leading competitors ensures we pack 3X the quantity of active ingredient in every tablet compared to most others.

Absorbed Like a Sponge

Black pepper extract is included to enhance the absorption of 5-HTP, increasing it by up to 2000%.

Exceptional Value For Money

With a full daily dose in each tablet, every bottle of 90 tablets lasts up to 3 months.

Maximum Potency

Containing a full daily dose of Vitamins B6 and C, both essential in the conversion of 5-HTP to serotonin.

Proudly made in the USA and the UK to the strictest of standards

more 5-HTP

At Pureclinica, we have a long history of producing highly effective health supplements going all the way back to 2005.

Our Triple Strength 5-HTP supplement continues this tradition.

Each tablet provides 300mg of highly concentrated 5-HTP extract, which is triple the strength of most 5-HTP supplements and up to 6x the strength of many others.

Although you may see similar strengths advertised elsewhere, most other brands require you to take 3 or more tablets to get the stated dose. Our 3x-strength 5-HTP gives you a complete dosage in just one tablet, making it a simpler and more cost-effective option.

A more effective 5-HTP

Some 5-HTP supplements not only suffer from low quantities of the active ingredient, but also poor absorption and low biological efficacy.

To create a more effective 5-HTP supplement, we started by first examining how it is manufactured, seeking to reduce any impurities in the raw powder, and secondly, through research into how 5- HTP is converted into serotonin, leading to the inclusion of bio-enhacing enzymatic nutrients.

We work only with purposefully selected harvests of Griffonia simplicifolia seeds from which 5- HTP is extracted. We then utilize advanced manufacturing and purification processes that result in a superior raw ingredient, with less impurities and a purer, more biologically available 5-HTP.

These processes include microfiltration, liquid chromatography, and crystallization. To further enhance the absorption, we included the correct dose of 5mg of Black Pepper Extract, which increases the uptake of other nutrients by up to 2000%.

For 5-HTP to be converted to serotonin, a process known as “decarboxylation” is required. Both Vitamins B6 and C are essential in this process, so we included a full daily dose of both in each tablet. Without these additional nutrients, any 5-HTP you take may be wasted.

We maintain the highest standards by employing a rigorous testing protocol during manufacturing, and third-party testing afterwards to verify the quality, purity, and accuracy of label claims.

This unique combination of high-quantity, high-quality, and maximized potency elevates Triple Strength 5-HTP to a class all of its own, and the only choice if you want a truly effective 5-HTP supplement.

We believe everyone should be able to take Triple Strength 5-HTP, so we offer it at affordable prices in bottles containing 90 tablets, up to three months supply, providing excellent value for money, especially when compared to lower strength, lower quality products.

Key ingredients

5-HTP 300mg

5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid that is converted into serotonin, a neurotransmitter that is involved in a wide range of functions in the body, including regulation of mood and sleep.


5-HTP is derived from the amino acid tryptophan and can be found in small amounts in certain foods such as turkey, chicken, milk, and some fruits and vegetables.

References:
EFSA. 5-HTP contributes to normal functioning of nervous system. (2012). Retrieved from https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2012.2816

EFSA. 5-HTP contributes to normal sleep-wake cycle. (2010). Retrieved from https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2010.1607

Vitamin C 50mg

Vitamin C helps improve the efficacy of 5-HTP by converting 5-HTP intoserotonin, a neurotransmitter that regulates mood, sleep, and appetite. Vitamin C is required for this conversion to occur effectively. By providing adequate levels of vitamin C, the conversion of 5- HTP into serotonin can be improved, potentially enhancing the effects of 5-HTP supplementation.

References:
European Food Safety Authority (EFSA). (2021). Scientific opinion on the safety of vitamin C. https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2021.6410

Vitamin B (Pyridoxine hydrochloride) 15mg

Vitamin B6 helps in the production of neurotransmitters, including serotonin and
norepinephrine, which regulate mood, sleep, and appetite. Vitamin B6 may enhance the effects of 5-HTP supplementation by facilitating the conversion of 5-HTP into serotonin.

References:
European Food Safety Authority (EFSA). (2021). Scientific opinion on the safety of Vitamin B6
(pyridoxine). https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2021.6413

Black Pepper Extract 5mg

Black pepper extract is a natural compound found in black pepper that has been shown to enhance the bioavailability of certain nutrients, including vitamins and minerals.

References:
Balfego F, et al. (2015). Bioavailability of black pepper extract in humans: a review of its pharmacokinetics, efficacy and safety. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391529/

Product Facts

90 tablets per bottle

Each tablet includes:

300mg 5-HTP

50mg Vitamin C

15mg Vitamin B6

5mg Black Pepper Extract

Store in a cool dry place, away from direct sunlight.
Warning:

Keep away from children.

DOES NOT Contain:

Yeast, wheat, milk, eggs, gluten, soy, gelatin, peanuts, shellfish, or dairy.

Supplement Facts

Serving Size: 1 tablet

Servings Per Container: 90

  • Ingredients

    Amount Per Serving

    % Daily Value*

  • 5-HTP

    300mg

    **

  • Vitamin C

    50mg

    **

  • Vitamin B6 (Pyridoxine hydrochloride)

    15mg

    1000

  • Black Pepper Extract

    5mg

    **

*Percent Daily Values are based on a 2000 calorie diet. **No Daily Valuos established

Other ingredients:

Bulking Agents (Microcrystalline cellulose), Anti-caking Agent (vegetable magnesium salts of fatty acids, Coating (Hypromellose Glycerine).

Suggested Use:

Take one tablet daily, preferably with a meal. Do not exceed stated dose.

Customer Reviews

Based on 88 reviews
75%
(66)
23%
(20)
0%
(0)
0%
(0)
2%
(2)
D
Dave G (Preston, GB)
5HTP

I've been using this product for 2 weeks now and there are small signs of my old self returning - many thanks.

H
Hayley Smith (St Albans, GB)
Great product

Have been taking these for 3 months and have seen a huge difference. Also super speedy delivery!

A
Amanda Dais
Perfect anti-dote to a restless mind

The sleep hype is real, you can NOT wake me when I take this regularly. I don't know if it's the imrpoved sleep, or the 5HTP, but I feel happy and great when I wake up too.

T
Tímea Benyicka (Leicester, GB)
Not received

Unfortunately my parcel never arrived. I connected the Royal Mail regarding the problem but they was unable to get a hold of the person who received it. I tried to contact the seller on a phone number provided with no luck so far so quite disappointed as it was a little ,,present,, for a deeply depressed friend who wants to try to get out from depression with natural help.

Hi there,
Thank you for taking the time to leave a review. I am sorry to learn of your experience with my company and that your parcel did not arrive, and that you were unable to reach us by phone.
I completely understand how disappointing and frustrating it is when ordering something and it not arriving, especially since it was meant to be a gift for your friend.
I am not sure what happened to your order. The information shows it was received but from your review it seems the Royal Mail have left it with someone other than you. Unfortunately the Royal Mail can not give us any information as we are not the recipient.

With that said, please reach out to us at sales@pureclinica.com and my customer care staff will resolve this for you immediately. Either by way of refund or we can arrange to ship the order again.
Kind regards,
Andrew

S
Steve Martin (Newcastle upon Tyne, GB)
Excellent quality and value

This was pretty much the only supplier selling 5-HTP at reasonable dosage (300mg) and the price and customer service was very good.

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Frequently Asked Questions

How does Vitamin B6 and Vitamin C help with 5-HTP conversion?

Vitamin B6 and Vitamin C play critical roles in the conversion of 5-HTP to serotonin. This conversion process, known as decarboxylation, involves the removal of a carboxyl group from 5-HTP to form serotonin. Vitamin B6 acts as a coenzyme for the enzyme aromatic L-amino acid decarboxylase, which catalyzes this reaction. Without adequate Vitamin B6, this enzymatic activity is reduced, leading to inefficient conversion of 5-HTP.

Vitamin C, on the other hand, serves as a potent antioxidant and maintains the stability of the decarboxylase enzyme and the overall cellular environment where the conversion occurs. It also supports the regeneration of tetrahydrobiopterin (BH4), a crucial cofactor for the production of neurotransmitters including serotonin. By providing both vitamins in our supplement, we ensure that the 5-HTP you take is efficiently converted to serotonin, maximizing its benefits for mood, sleep, and overall well-being.

Is it safe to take 5-HTP long-term?

For most people, 5-HTP is safe for long-term use when taken as directed. However, it is always best to periodically review your supplement regimen with your healthcare provider to ensure it remains appropriate for your health needs.

Can I take 5-HTP with medications?

If you are currently taking any medications, especially antidepressants or other serotonin-related pills, it is crucial to consult with your healthcare provider before taking 5-HTP to avoid any potential interactions.

What is 5-HTP and how does it work?

5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid and chemical precursor to serotonin, a neurotransmitter that helps regulate mood and sleep. 5-HTP is converted into serotonin through a process known as decarboxylation, which is enhanced by the presence of vitamins B6 and C included in our supplement.

Quality Manufacturing And Testing

Our supplements start life as quality natural ingredients sourced globally. These are then processed and manufactured into high strength supplements in the UK,to CGMP and ISO standards, in BRC accredited facilities...That's just the start.

To ensure pureity and accurate label claims, every step of our supply chain is rigorously scrutinized and tested, from start to finish.

But even then our work is still not done.

We send batches of our products to 3rd party testing laboratories for additional analysis and testing.

So you can be confident you are receiving the strongest, purest, and best possible quality supplement

Find Out More

FOR EVERY BOTTLE YOU BUY A TREE IS PLANTED ON YOUR BEHALF

A tiny sapling goes a long way. Through our partnership with Eden Reforestation Projects, we are helping to plant trees on a massive scale.

Every bottle you purchase helps to protect vital eco-systems, help mitigate climate change, and create jobs that help provide education, health care, and food for rural communities in Mozambique, Nepal, Madagascar, and Ethiopia.

Our aim is to plant 10 million trees by 2030.

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